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Cell 69 , 1125 (1992)
NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability
In isolated hepatocytes, treatment with electrophilic agents depletes intracellular GSH Methionine transport Na+ independent Not responsive to either adaptive control or hormonal stimulation Cys, Met, and Cys transport Rat hepatocytes cultured for 24 h, the rate of uptake of cysteine is about 3-fold higher than that of methionine and 13-fold higher than that of cystine